Overview
Erythromycin with benzoyl peroxide is a combination topical treatment for acne that’s available only with a doctor’s prescription. Sold under the trade name Benzamycin Pak, this gel is uniquely packaged so that benzoyl peroxide and erythromycin don’t come into contact with each other until it’s time to use the medication. This acne medication must be prepared and used properly to get the best benefits from treatment and avoid unwanted side effects.
Function
Benzoyl peroxide with erythromycin treats acne by keeping your skin clear of the bacteria that contribute to acne, as well as keeping pores unclogged. Benzoyl peroxide is an active ingredient found in many over-the-counter acne treatments and prescription topical medications, says the American Academy of Dermatology (AAD). Topical erythromycin is a broad-spectrum antibiotic that’s also tough on acne. When combined with benzoyl peroxide, patients receive the benefit of two types of antimicrobials, says the AAD, which makes Benzamycin Pak very effective.
Use
Benzoyl peroxide with erythromycin should be applied to skin that’s been washed with a mild cleanser and blotted dry, according to the Mayo Clinic. Benzamycin Pak comes in a foil pouch with two separate compartments; those using this medication squeeze these into the palm of one hand and mix the benzoyl peroxide and erythromycin together. After applying it to the areas of skin affected by acne, the hands should be washed well.
Side Effects
Clinical trials submitted to the U.S. Food and Drug Administration (FDA) studied 550 acne patients, 236 of whom used benzoyl peroxide with erythromycin (Benzamycin Pak). The control group was given a placebo. The most common side effect reported by participants was dry skin (7.6 percent). Stinging, burning, tingling and erythema upon application of the medication was reported by 2.5 percent of Benzamycin Pak users. Fewer than 2 percent of participants reported other side effects, such as blepharitis, pruritus, photosensitivity and peeling skin.
Precautions
The FDA warns that use of additional acne treatment should be approached with caution, as this can irritate the skin and cause it to peel. Similarly, those using benzoyl peroxide with erythromycin should avoid using skin care products that are abrasive or that contain harsh, irritating ingredients. To reduce irritation, the Mayo Clinic advises waiting a half hour after washing or shaving before using Benzamycin Pak. This medication makes skin more susceptible to ultraviolet rays, so sun exposure should be restricted. The Mayo Clinic advises wearing sunscreen and wearing protective clothing and a hat when going outdoors. Benzoyl peroxide has a bleaching effect on colored fabrics and even hair, cautions the AAD; if this medication is applied to the back, neck or chest, it may be wise to put on an old T-shirt.
Effectiveness
Results of two clinical studies submitted to the FDA indicate that benzoyl peroxide with erythromycin is an effective topical treatment for acne. One study yielded a 48 percent reduction of inflammatory and noninflammatory lesions after eight weeks of use; a second study indicated a 45 percent reduction in lesions. The Mayo Clinic notes that if acne shows no improvement after three to four weeks of Benzamycin Pak (or if acne becomes markedly worse), this should be reported to the prescribing doctor.
